Platelet Antiheparin Activity: Storage Site and Release Mechanism

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Platelet antiheparin activity: storage site and release mechanism.

s 609 Book Reviews 619 Books Received for Review 622 Correspondence: CLL and Ph1; Plasmacytes 623 American Society of Hematology 627 For personal use only. on August 15, 2017. by guest www.bloodjournal.org From

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In Vivo Release and Turnover of Secreted Platelet Antiheparin

Human and rhesus monkey platelets secrete at least two antiheparin proteins: platelet factor 4 (PF4) and low affinity platelet factor 4 (LA-PF4). Neither of these proteins showed species-related antigenic differences. As determined by radioimmunoassay, the levels of PF4 and LA-PF4 antigen per 1 0 monkey platelets amounted to 1 0.7 and 20.3 gig, respectively. One milliliter of monkey plasma prep...

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In vivo release and turnover of secreted platelet antiheparin proteins in rhesus monkey (Macaca mulatta).

Human and rhesus monkey platelets secrete at least two antiheparin proteins: platelet factor 4 (PF4) and low affinity platelet factor 4 (LA-PF4). Neither of these proteins showed species-related antigenic differences. As determined by radioimmunoassay, the levels of PF4 and LA-PF4 antigen per 10(9) monkey platelets amounted to 10.7 and 20.3 microgram, respectively. One milliliter of monkey plas...

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The mechanism of platelet release.

The mechanism of platelet release has been studied in mouse bone marrow, using scanning and transmission electron microscopy. Cytoplasmic processes extended into sinusoids by megakaryocytes were found to undergo attenuation, and at the distal end develop constrictions between segments of platelet size. Rupture at sites of constriction is thought to release platelets. Microtubules were present i...

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In Vivo Release and Turnover of Secreted Platelet Antiheparin Proteins in Rhesus Monkey

Human and rhesus monkey platelets secrete at least two antiheparin proteins: platelet factor 4 (PF4) and low affinity platelet factor 4 (LA-PF4). Neither of these proteins showed species-related antigenic differences. As determined by radioimmunoassay, the levels of PF4 and LA-PF4 antigen per 1 0 monkey platelets amounted to 1 0.7 and 20.3 gig, respectively. One milliliter of monkey plasma prep...

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ژورنال

عنوان ژورنال: Blood

سال: 1974

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v44.2.157.157